ire-1

Symbol: ire-1
Name: IRE1 kinase related 1
Entrez gene ID: 174305
Ensembl gene ID: C41C4.4
Species: Worm (Taxid: 6239)

Functional description:
Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices xbp-1 precursor mRNA to produce the mature form which then induces transcription of UPR target genes. Unfolded protein response (UPR) transcripional activation by ire-1, as well as translational attenuation by pek-1 in a complementary pathway, maintains ER homeostasis. Ire-1 and pek-1 are redundant genes that control a pathway essential for larval development and survival. [UniProt]

Observation:

ire-1 mutation reduces slightly the lifespan under AL, but reduces significantly the lifespan extension by DR. ire-1 mutant has a significantly reduced slope in mean lifespan versus food concentrations relative to wild-type. ire-1 mutation fully suppresses lifespan extension by hif-1 mutation under AL and DR conditions [19461873].



Interventions:
  • ire-1 mutation

  • Assays: Organismal Lifespan

    Classification:
  • DR-Essential


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • ERN1 (9606)
  • ERN1 (9598)
  • ERN1 (9615)
  • ERN1 (9913)
  • Ern1 (10090)
  • Ern1 (10116)
  • ERN1 (9031)
  • ern2 (7955)
  • ire-1 (7227)
  • AgaP_AGAP004176 (7165)
  • ire-1 (6239)

  • Orthologs
  • ERN2 (9544)
  • ERN1 (9606)
  • ERN2 (9606)
  • Ern2 (10090)
  • LOC698026 (9544)
  • Ire1 (7227)
  • ERN1 (9544)
  • Ern2 (10116)
  • IRE1 (4932)
  • Ire1 (7227)
  • Ern1 (10116)
  • Ern1 (10090)
  • ERN2 (9544)
  • ERN1 (9606)
  • ERN2 (9606)
  • Ern2 (10090)
  • LOC698026 (9544)
  • Ire1 (7227)
  • ERN1 (9544)
  • Ern2 (10116)
  • IRE1 (4932)
  • Ire1 (7227)
  • Ern1 (10116)
  • Ern1 (10090)



  • Edit \ Update (Admin) | Delete

    Comment on This Data Unit