phb-2

Symbol: phb-2
Name: mitochondrial ProHiBitin complex 2
Entrez gene ID: 174034
Ensembl gene ID: T24H7.1
Species: Worm (Taxid: 6239)

Functional description:
PHB proteins are essential during embryonic development and are required for somatic and germline differentiation in the larval gonad. A deficiency in PHB proteins results in altered mitochondrial biogenesis in body wall muscle cells. [UniProt]

Observation:

phb-2 RNAi shortens lifespan of wild type, aak-2, cep-1 (p53) and jnk-1 mutants, but increases lifespan of daf-2, daf-7, daf-4, daf-11, gas-1, mev-1, isp-1, clk-1, nhr-49, fat-7, gld-1 mutants. daf-16 mutation fully suppressed exceptionally long-lifespan of via RNAi prohibitin-depleted, daf-2 mutants [19812672].



Interventions:
  • phb-2 RNAi

  • Assays: Organismal Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • PHB2 (9606)
  • PHB2 (9598)
  • PHB2 (9615)
  • PHB2 (9913)
  • Phb2 (10090)
  • Phb2 (10116)
  • PHB2 (9031)
  • zgc:86841 (7955)
  • LOC100332994 (7955)
  • phb2 (7955)
  • l(2)03709 (7227)
  • AgaP_AGAP009642 (7165)
  • phb-2 (6239)
  • phb2 (4896)
  • PHB2 (4932)
  • KLLA0E15731g (28985)
  • AGOS_ADL141W (33169)
  • GeneID:2680930 (148305)
  • NCU03310 (5141)
  • ATPHB6 (3702)
  • ATPHB1 (3702)
  • ATPHB2 (3702)
  • ATPHB7 (3702)
  • Os03g0841700 (4530)
  • Os07g0262200 (4530)
  • PF10_0144 (5833)

  • Orthologs
  • Phb2 (10090)
  • phb2 (4896)
  • PHB2 (4932)
  • LOC714693 (9544)
  • PHB2 (9606)
  • Phb2 (10116)
  • l(2)03709 (7227)
  • Phb2 (10090)
  • phb2 (4896)
  • PHB2 (4932)
  • LOC714693 (9544)
  • PHB2 (9606)
  • Phb2 (10116)
  • l(2)03709 (7227)



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