Symbol: Arntl Name: aryl hydrocarbon receptor nuclear translocator-like Entrez gene ID: 11865 Ensembl gene ID: ENSMUSG00000055116 Species: Mouse (Taxid: 10090) Functional description: Appears to be involved in circadian rhythyms; ARNTL-CLOCK heterodimers activate E-box element (3'- CACGTG-5') transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins (By similarity). [UniProt] Observation: Arntl knockout mice display symptoms of premature aging including a shorter lifespan, sarcopenia, cataracts, less subcutaneous fat, and organ shrinkage [16847346]. Assays: Organismal Lifespan Classification: References: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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