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Symbol: Thor Alias: CG8846; d4E-BP; eIF4E Entrez gene ID: 33569 Ensembl gene ID: FBgn0261560 Species: Fly (Taxid: 7227) Functional description: CG8846 gene product from transcript CG8846-RA; Thor [Source:FlyBase gene name;Acc:FBgn0261560] [Ensembl]; The gene Thor is referred to in FlyBase by the symbol Dmel\Thor (CG8846, FBgn0261560). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: eukaryotic initiation factor 4E binding. There is experimental evidence that it is involved in the biological process: response to starvation; immune response; determination of adult lifespan; response to oxidative stress; regulation of cell growth; triglyceride metabolic process; negative regulation of cell size; response to stress; antibacterial humoral response; regulation of mitochondrial translation. 28 alleles are reported. The phenotypes of these alleles are annotated with: wing disc; 1st posterior cell; retina; embryonic/larval fat body; wing; type I bouton; adult brain; abdominal adult fat mass; muscle cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Eukaryotic translation initiation factor 4E binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 18-24 hour embryonic stages, at stages throughout the larval period, during early pupal stages, in stages of adults of both sexes. [FlyBase] Observation: Null mutation in Thor (alias d4E-BP) causes a significant decrease in longevity (-25% median lifespan in males). Thor is strongly upregulated during starvation. foxo and Thor null mutants are compromised in stress resistant. Stress resistance of foxo null mutants is rescued by Thor overexpression [16055649]. Thor is upregulated on the protein level in a foxo-independent manner upon DR, while it is transcriptional induced in a foxo-dependent fashion by starvation. Thor null mutants cancel out DR-induced lifespan extension, because mutants exhibit a diminished change in lifespan when nutrient conditions were varied. Ubiquitously expression of Thor rescued DR response in females and males. Thor null mutants have a wild-type similar reduction in egg production upon DR. Ubiquitously overexpression of wild-type Thor causes no change under AL, but an activated allele (with more than 3-fold increased binding activity to delF4E) significantly extends lifespan of females (weak allele) and females as well as males (strong allele). Mean lifespan is extended by 11 to 40%. Median lifespan of males and females is enhanced by by 11 and 22%, respectively. Maximum lifespan is extended by 16 and 18% for males and females, respectively. Under DR (0.25% YE) there is no lifespan extension, beyond the effect of DR alone, in all (wild-type, weak and strong) Thor alleles [19804760]. Lifespan of animals with increased Pten and 4E-BP activity in muscle exhibit and extended mean and maximum lifespan by 20% and 15.8% [21111239]. Interventions: Assays: Organismal Lifespan Mean: +11 to +22 Median: -25 to +40 Maximum: +16 to +18 Classification: Type: References: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Orthologs Inparanoids Note: Is the reference about Pten and Thor about Pten overexpression alone? Edit \ Update (Admin) | Delete |
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