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Symbol: l(3)neo18 Name: lethal (3) neo18 Alias: CG9762 Entrez gene ID: 46260 Ensembl gene ID: FBgn0011455 Species: Fly (Taxid: 7227) Functional description: lethal (3) neo18; lethal (3) neo18 [Source:FlyBase gene name;Acc:FBgn0011455] [Ensembl]; The gene lethal (3) neo18 is referred to in FlyBase by the symbol Dmel\l(3)neo18 (CG9762, FBgn0011455). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: NADH dehydrogenase activity; NADH dehydrogenase (ubiquinone) activity. There is experimental evidence that it is involved in the biological process: determination of adult lifespan; response to reactive oxygen species. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, during late pupal stages, in stages of adults of both sexes. [FlyBase] Observation: RNA interference of l(3)neo18 in females increases mean lifespan by 14-18% when applied during development and adulthood in the whole organism and by 8-24% when applied in the neurons. The effect is more variable in males. A consistent increase (8-18%) is however observed for whole organisms RNAi in adults [19747824]. l(3)neo18 (alias CG9762) is translational upregulated upon DR. Under rich nutritional conditions lifespan of l(3)neo18 RNAi knockout animals is indistinguishable from wild-type, while upon DR, lifespan extension is diminished in males and females [19804760]. Interventions: Assays: Organismal Lifespan Mean: +8 to +24 Classification: Type: References: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Orthologs Inparanoids Edit \ Update (Admin) | Delete |
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