Denigma

HHF1

Symbol: HHF1
Name: Histone H Four 1
Entrez gene ID: 852294
Ensembl gene ID: YBR009C
Species: Yeast (Taxid: 4932)

Functional description:
Hhf1p; Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity [Source:SGD;Acc:S000000213] [Ensembl]

Observation:

HHF1 deletion extends mean and maximum replicative by 45 and 69%, respectively, as well as chronological lifespan. Chronological lifespan extension by HHF1 deletion and DR is non-synergistic. DR appears to extend replicative lifespan more when combined with hhf1 mutation, whereas DR does not change hhf1-induced replicative lifespan extension, suggesting a positive interaction [21584246].



Interventions:
  • HHF1 deletion

    • Assays: Replicative Lifespan Chronological Lifespan
    Mean: +45
    Maximum: +69

    Classification:
  • Gerontogene
  • Positive Gerontogene
  • DR-Essential


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • HIST1H4F (9606)
  • HIST2H4B (9606)
  • HIST1H4J (9606)
  • HIST4H4 (9606)
  • HIST1H4K (9606)
  • HIST1H4A (9606)
  • HIST1H4L (9606)
  • HIST1H4H (9606)
  • HIST2H4A (9606)
  • HIST1H4B (9606)
  • HIST1H4E (9606)
  • HIST1H4C (9606)
  • HIST1H4D (9606)
  • HIST1H4I (9606)
  • LOC735611 (9598)
  • LOC465305 (9598)
  • LOC736707 (9598)
  • LOC457262 (9598)
  • LOC748532 (9598)
  • LOC462507 (9598)
  • LOC748540 (9598)
  • LOC472228 (9598)
  • LOC748545 (9598)
  • LOC748525 (9598)
  • LOC748513 (9598)
  • LOC611513 (9615)
  • LOC525863 (9913)
  • LOC679840 (10116)
  • LOC417946 (9031)
  • H4-VII (9031)
  • LOC770005 (9031)
  • LOC770142 (9031)
  • LOC770079 (9031)
  • LOC427884 (9031)
  • zgc:153409 (7955)
  • His4:CG33881 (7227)
  • His4:CG33869 (7227)
  • His4:CG33879 (7227)
  • His4:CG33877 (7227)
  • hhf1 (4896)
  • hhf2 (4896)
  • hhf3 (4896)
  • HHF1 (4932)
  • HHF2 (4932)
  • KLLA0E08613g (28985)
  • KLLA0E08647g (28985)
  • AGOS_ADL201W (33169)
  • GeneID:2684448 (148305)
  • GeneID:2675181 (148305)
  • NCU00212 (5141)
  • NCU01634 (5141)
  • AT5G59690 (3702)
  • HIS4 (3702)
  • AT5G59970 (3702)
  • AT3G45930 (3702)
  • AT3G46320 (3702)
  • AT3G53730 (3702)
  • AT1G07660 (3702)
  • AT1G07820 (3702)
  • Os01g0835900 (4530)
  • PF11_0061 (5833)

    • Orthologs
  • His4:CG33905 (7227)
  • His4:CG33899 (7227)
  • His4:CG33875 (7227)
  • His4:CG33883 (7227)
  • LOC679983 (10116)
  • Hist1h4c (10090)
  • his-50 (6239)
  • his-28 (6239)
  • his-18 (6239)
  • his-26 (6239)
  • Hist1h4n (10090)
  • His4:CG33887 (7227)
  • HIST1H4I (9606)
  • His4:CG33891 (7227)
  • His4:CG33897 (7227)
  • his-37 (6239)
  • hhf2 (4896)
  • HIST4H4 (9606)
  • HIST1H4A (9606)
  • HIST1H4D (9606)
  • HIST1H4F (9606)
  • HIST1H4K (9606)
  • HIST1H4J (9606)
  • HIST1H4C (9606)
  • HIST1H4H (9606)
  • HIST1H4B (9606)
  • HIST1H4E (9606)
  • HIST1H4L (9606)
  • HIST2H4A (9606)
  • his-1 (6239)
  • Hist1h4f (10090)
  • his-10 (6239)
  • His4:CG33901 (7227)
  • his-31 (6239)
  • LOC698354 (9544)
  • his-38 (6239)
  • his-5 (6239)
  • His4:CG33873 (7227)
  • LOC696253 (9544)
  • His4:CG33881 (7227)
  • His4:CG33907 (7227)
  • RGD1565073 (10116)
  • Hist1h4h (10090)
  • His4:CG33885 (7227)
  • His4:CG33871 (7227)
  • His4r (7227)
  • His4:CG33877 (7227)
  • HIST2H4B (9606)
  • His4:CG33903 (7227)
  • his-60 (6239)
  • his-67 (6239)
  • His4:CG31611 (7227)
  • hhf1 (4896)
  • his-46 (6239)
  • his-56 (6239)
  • his-64 (6239)
  • His4:CG33893 (7227)
  • His4:CG33889 (7227)
  • His4:CG33879 (7227)
  • LOC679840 (10116)
  • His4:CG33895 (7227)
  • his-14 (6239)
  • HIST1H4G (9606)
  • His4:CG33869 (7227)
  • hhf3 (4896)
  • LOC699317 (9544)
  • Hist1h4a (10090)
  • His4:CG33909 (7227)
  • His4:CG33905 (7227)
  • His4:CG33899 (7227)
  • His4:CG33875 (7227)
  • His4:CG33883 (7227)
  • LOC679983 (10116)
  • Hist1h4c (10090)
  • his-50 (6239)
  • his-28 (6239)
  • his-18 (6239)
  • his-26 (6239)
  • Hist1h4n (10090)
  • His4:CG33887 (7227)
  • HIST1H4I (9606)
  • His4:CG33891 (7227)
  • His4:CG33897 (7227)
  • his-37 (6239)
  • hhf2 (4896)
  • HHF2 (4932)
  • HIST4H4 (9606)
  • HIST1H4A (9606)
  • HIST1H4D (9606)
  • HIST1H4F (9606)
  • HIST1H4K (9606)
  • HIST1H4J (9606)
  • HIST1H4C (9606)
  • HIST1H4H (9606)
  • HIST1H4B (9606)
  • HIST1H4E (9606)
  • HIST1H4L (9606)
  • HIST2H4A (9606)
  • his-1 (6239)
  • Hist1h4f (10090)
  • his-10 (6239)
  • His4:CG33901 (7227)
  • his-31 (6239)
  • LOC698354 (9544)
  • his-38 (6239)
  • his-5 (6239)
  • His4:CG33873 (7227)
  • LOC696253 (9544)
  • His4:CG33881 (7227)
  • His4:CG33907 (7227)
  • RGD1565073 (10116)
  • Hist1h4h (10090)
  • His4:CG33885 (7227)
  • His4:CG33871 (7227)
  • His4r (7227)
  • His4:CG33877 (7227)
  • HIST2H4B (9606)
  • His4:CG33903 (7227)
  • his-60 (6239)
  • his-67 (6239)
  • His4:CG31611 (7227)
  • hhf1 (4896)
  • his-46 (6239)
  • his-56 (6239)
  • his-64 (6239)
  • His4:CG33893 (7227)
  • His4:CG33889 (7227)
  • His4:CG33879 (7227)
  • LOC679840 (10116)
  • His4:CG33895 (7227)
  • his-14 (6239)
  • HIST1H4G (9606)
  • His4:CG33869 (7227)
  • hhf3 (4896)
  • LOC699317 (9544)
  • Hist1h4a (10090)
  • His4:CG33909 (7227)



    • Edit \ Update (Admin) | Delete

    Comment on This Data Unit