SFA1

Symbol: SFA1
Name: Sensitive to FormAldehyde 1
Alias: ADH5
Entrez gene ID: 851386
Ensembl gene ID: YDL168W
Species: Yeast (Taxid: 4932)

Functional description:
Sfa1p; Bifunctional enzyme containing both alcohol dehydrogenase and glutathione-dependent formaldehyde dehydrogenase activities, functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p [Source:SGD;Acc:S000002327] [Ensembl]

Observation:

sfa1;yhb1 double mutant cancels out the ability of moderate DR to extend replicative lifespan, but not chronological lifespan. Indicating that NO homeostasis is crucial during DR-induced replicative lifespan extension. Deleting YHB1 partially abolishes the DR-induced replicative lifespan extension, whereas deleting SFA1 alone had no effect. Yhb1 and Sfa1 may play redundant roles [21584246].



Interventions:
  • SFA1 deletion
  • SFA1 YHB1 double mutation

  • Assays: Replicative Lifespan

    Classification:
  • DR-Essential


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • ADH5 (9606)
  • ADH5 (9598)
  • ADH5 (9913)
  • Adh5 (10090)
  • ADH5 (9031)
  • adh5 (7955)
  • Fdh (7227)
  • AgaP_AGAP010499 (7165)
  • H24K24.3 (6239)
  • Y50D4C.2 (6239)
  • SPCC13B11.04c (4896)
  • SFA1 (4932)
  • KLLA0D12342g (28985)
  • AGOS_ACL148C (33169)
  • GeneID:2683964 (148305)
  • NCU06652 (5141)
  • HOT5 (3702)
  • Os02g0815500 (4530)

  • Orthologs
  • ADH5 (9606)
  • ADH7 (9544)
  • Adh1 (10090)
  • ADH7 (9606)
  • Adh7 (10090)
  • Adh5 (10090)
  • ADH6 (9606)
  • ADH6 (9544)
  • ADH1A (9606)
  • ADH4 (9544)
  • ADH5 (9544)
  • Y50D4C.2 (6239)
  • Adh7 (10116)
  • SPCC13B11.04c (4896)
  • Fdh (7227)
  • LOC697703 (9544)
  • Adh6a (10116)
  • H24K24.3 (6239)
  • Adh4 (10116)
  • Adh1 (10116)
  • ADH1C (9544)
  • ADH1B (9606)
  • Adh6 (10116)
  • Adh4 (10090)
  • Adh6a (10090)
  • ADH4 (9606)
  • ADH5 (9606)
  • ADH7 (9544)
  • Adh1 (10090)
  • ADH7 (9606)
  • Adh7 (10090)
  • Adh5 (10090)
  • ADH6 (9606)
  • ADH6 (9544)
  • ADH1A (9606)
  • ADH4 (9544)
  • ADH5 (9544)
  • Y50D4C.2 (6239)
  • Adh7 (10116)
  • SPCC13B11.04c (4896)
  • Fdh (7227)
  • LOC697703 (9544)
  • Adh6a (10116)
  • H24K24.3 (6239)
  • Adh4 (10116)
  • Adh1 (10116)
  • ADH1C (9544)
  • ADH1B (9606)
  • Adh6 (10116)
  • Adh4 (10090)
  • Adh6a (10090)
  • ADH4 (9606)



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