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Symbol: cyp-33E2 Name: CYtochrome P450 family 33E2 Entrez gene ID: 185653 Ensembl gene ID: F42A9.5 Species: Worm (Taxid: 6239) Functional description: Protein CYP-33E2; CYtochrome P450 family member (cyp-33E2) [Source:RefSeq peptide;Acc:NP_501470] [Ensembl]; cyp-33E2 encodes a cytochrome P450; when co-expressed with human CPR in vitro, CYP-33E2 exhibits monooxygenase activity on a variety of long-chain fatty acid substrates, including eicosapentaenoic acid and arachidonic acid; cyp-33E2(RNAi) animals show reduced rates of pharyngeal pumping, suggesting that CYP-33E2-generated metabolites may play a role in regulating pharyngeal muscle contraction; a cyp-33E2::GFP reporter fusion is expressed in the pharynx, particularly in the pharyngeal marginal cells, throughout larval development and adulthood. [WormBase] Observation: RNA interference of cyp-33E2 increases mean lifespan by 18% [17608836]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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