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Symbol: Eip55E Name: Gamma-Cystathioinase Alias: CG5345; Dmel\CG5345; Eip40; EIP40; Eip55BD Entrez gene ID: 37143 Ensembl gene ID: FBgn0000566 Species: Fly (Taxid: 7227) Functional description: CG5345 gene product from transcript CG5345-RA; Eip55E [Source:FlyBase gene name;Acc:FBgn0000566] [Ensembl]; The gene Eip55E is referred to in FlyBase by the symbol Dmel\Eip55E (CG5345, FBgn0000566). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: cystathionine gamma-lyase activity. It is reported to be involved in the biological process: sulfur amino acid metabolic process. 7 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; Pyridoxal phosphate-dependent transferase, major domain; Pyridoxal phosphate-dependent transferase, major region, subdomain 1; Pyridoxal phosphate-dependent transferase, major region, subdomain 2. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-06 hour embryonic stages, during early larval stages. [FlyBase] Observation: Propargylglycine (PPG) inhibits gamma-cystathioinase, the second enzyme of the trans-sulfuration pathway (TSP). PPG is a specific suicidal inhibitor of gamma-cystathionase Eip55E. Gluthatione (GSH) levels are decreased by PPG administration in flies subjected to DR, whereas there is no effect on fully fed animals. PPG robustly suppresses DR lifespan extension, while longevity of fully fed flies is not affected in different strains. Thus, indicating that the effect of PPG is specific to DR. PPG abrogates changes in lifespan that are normally observed when flies are maintained in different dietary concentrations and compositions [21930912]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Inparanoids Edit \ Update (Admin) | Delete |
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