Denigma

ERG2

Symbol: ERG2
Name: ERGosterol biosynthesis 2
Alias: END11
Entrez gene ID: 855242
Ensembl gene ID: YMR202W
Species: Yeast (Taxid: 4932)

Functional description:
Erg2p; C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis [Source:SGD;Acc:S000004815] [Ensembl]

Observation:

Overexpression of ERG2 with the promoter of ERG6 (Perg6-ERG2) extends replicative lifespan and this effect was overlapping with moderate DR, because DR can not extend the lifespan of this mutant [Tang et al., unpublished].

Perg6-ERG2 does not extend the lifespan significantly on normal medium, but it reverses the effect of DR. DR greatly shortens the lifespan of Perg6-ERG2 mutants. Perg6-ERG2 shortens the lifespan of nyv1 deletion mutations [Xia et al. unpublished].

Deletion of OSH5 greatly shortens the lifespan of Perg6-ERG2. SIR2 overxpression extends the lifespan of Perg6-ERG2 [Xia et al. unpublished].



Interventions:
  • ERG2 overexpression

    • Assays: Replicative Lifespan

    Classification:
  • Aging-Suppressor
  • Positive Aging-Suppressor
  • DR-Essential


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • SIGMAR1 (9606)
  • SIGMAR1 (9598)
  • SIGMAR1 (9615)
  • SIGMAR1 (9913)
  • Sigmar1 (10090)
  • Sigmar1 (10116)
  • sigmar1 (7955)
  • erg2 (4896)
  • ERG2 (4932)
  • KLLA0F06336g (28985)
  • AGOS_AFL181C (33169)
  • GeneID:2679059 (148305)
  • NCU04156 (5141)

    • Note: Perg6-ERG2 does not extend the lifespan significantly on normal medium, is probaly wrong as it extends the lifespan.

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