FKH1

Symbol: FKH1
Name: ForK head Homolog 1
Entrez gene ID: 854675
Ensembl gene ID: YIL131C
Species: Yeast (Taxid: 4932)

Functional description:
Fkh1p; Forkhead family transcription factor with a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; regulates donor preference during switching [Source:SGD;Acc:S000001393] [Ensembl]

Observation:

Deletion of FKH1 or FKH2 has no effect on neither replicative, nor chronological lifespan [18225956]. Deletion of both FKH1 and FKH2 reduces mean chronological lifespan by 50% and abrogates lifespan extension and increased stress resistance conferred from water starvation (extreme DR). Modest increase in FKH1 or FKH2 expression results in a slight increased chronological and replicative lifespan as well as stress resistance [22438832].



Interventions:
  • FKH1 FKH2 deletion

  • Assays: Chronological Lifespan

    Classification:
  • DR-Essential


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • FKH1 (4932)
  • GeneID:2684413 (148305)
  • NCU00019 (5141)



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