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Symbol: COX4 Name: Cytochrome c OXidase 4 Entrez gene ID: 852688 Ensembl gene ID: YGL187C Species: Yeast (Taxid: 4932) Functional description: Cox4p; Subunit IV of cytochrome c oxidase, the terminal member of the mitochondrial inner membrane electron transport chain; precursor N-terminal 25 residues are cleaved during mitochondrial import; phosphorylated; spermidine enhances translation [Source:SGD;Acc:S000003155] [Ensembl] Observation: COX4 (subunit of cytochrome oxidase) deletion decreases mitochondrial membrane potential in rho+ cells to a value intermediate between rho+ and rho0 as well as increases mean and maximum replicative lifespan by 24% and 55%, respectively. Deletion of either RTG2 or RTG3 abrogated the replicative lifespan extension by COX4 deletion. ERC levels in cox4Delta rho+ cells was the same or lower than in rho+ cells [22303396]. Assays: Replicative Lifespan Mean: +24 Maximum: +55 Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Orthologs Edit \ Update (Admin) | Delete |
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