Symbol: MOT2 Name: Modulator Of Transcription 2 Alias: NOT4;SIG1 Entrez gene ID: 856799 Ensembl gene ID: YER068W Species: Yeast (Taxid: 4932) Functional description: Mot2p; Subunit of the CCR4-NOT complex, which has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p [Source:SGD;Acc:S000000870] [Ensembl]; Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications [SGD] Observation: Deletion of MOT2 increases mean chronological lifespan by 25 - 85% (25, 34, 41, 85) in diploid cells [21447998] Assays: Mean: +25-85 Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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