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Symbol: CCR4 Name: Carbon Catabolite Repression 4 Alias: FUN27;NUT21 Entrez gene ID: 851212 Ensembl gene ID: YAL021C Species: Yeast (Taxid: 4932) Functional description: Ccr4p; Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening [Source:SGD;Acc:S000000019] [Ensembl] Observation: Deletion of CCR4 increases mean chronological lifespan by 20 - 41% (20, 33, 41) in diploid cells [21447998]. In W303R CCR4 deletion shortens replicative lifespan by approximately 80% and results in temperature sensitivity that is suppressed by SSD1-V. SSD1-V partially suppresses the short-lifespan of ccr4 mutant. CCR4 mutation is synthetically lethal in combination with deletion of MPT5 in the absence of SSD1-V [11805047]. Interventions: Assays: Replicative Lifespan Mean: +20-41 Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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