Symbol: cul-1 Name: CULlin 1 Entrez gene ID: 176466 Ensembl gene ID: D2045.6 Species: Worm (Taxid: 6239) Functional description: Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. [UniProt] Observation: RNAi of cul-1 decreases lifespan of daf-2 mutant, but not of wild-type or glp-1 mutant. The CUL-1 complex functions in postmitotic, adult somatic tissues of insulin/insulin-like growth factor-1-signaling mutants to enhance longevity. It may act, at least in part, by promoting the transcriptional activity of DAF-16/FOXO [17392428]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Note: Is cul-1 a negative aging-suppressor? Edit \ Update (Admin) | Delete |
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