cul-1

Symbol: cul-1
Name: CULlin 1
Entrez gene ID: 176466
Ensembl gene ID: D2045.6
Species: Worm (Taxid: 6239)

Functional description:
Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. [UniProt]

Observation:

RNAi of cul-1 decreases lifespan of daf-2 mutant, but not of wild-type or glp-1 mutant. The CUL-1 complex functions in postmitotic, adult somatic tissues of insulin/insulin-like growth factor-1-signaling mutants to enhance longevity. It may act, at least in part, by promoting the transcriptional activity of DAF-16/FOXO [17392428].



Interventions:
  • cul-1 RNAi

  • Assays: Organismal Lifespan

    Classification:
  • Aging Associated
  • No Age Effect


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • CUL1 (9606)
  • CUL1 (9598)
  • CUL1 (9615)
  • CUL1 (9913)
  • Cul1 (10090)
  • Cul1 (10116)
  • CUL1 (9031)
  • cul1a (7955)
  • lin19 (7227)
  • AgaP_AGAP008007 (7165)
  • cul-1 (6239)
  • cul1 (4896)
  • GeneID:2683267 (148305)
  • NCU05204 (5141)

  • Note: Is cul-1 a negative aging-suppressor?

    Edit \ Update (Admin) | Delete

    Comment on This Data Unit