ACO1

Symbol: ACO1
Name: ACOnitase 1
Alias: GLU1
Entrez gene ID: 851013
Ensembl gene ID: YLR304C
Species: Yeast (Taxid: 4932)

Functional description:
Aco1p; Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy [Source:SGD;Acc:S000004295] [Ensembl]

Observation:

Deletion of ACO1 decreases mean chronological lifespan by 42 - 56% in diploid cells [21447998].



Interventions:
  • ACO1 deletion -42 to -56%

  • Assays: Chronological Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • ACO2 (9606)
  • ACO2 (9615)
  • ACO2 (9913)
  • Aco2 (10090)
  • Aco2 (10116)
  • ACO2 (9031)
  • aco2 (7955)
  • Acon (7227)
  • AgaP_AGAP007852 (7165)
  • aco-2 (6239)
  • SPAC24C9.06c (4896)
  • ACO1 (4932)
  • KLLA0C17314g (28985)
  • AGOS_ADL032W (33169)
  • GeneID:2676822 (148305)
  • NCU02366 (5141)



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