Denigma

ADE3

Symbol: ADE3
Name: ADEnine requiring 3
Entrez gene ID: 853118
Ensembl gene ID: YGR204W
Species: Yeast (Taxid: 4932)

Functional description:
Ade3p; Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine [Source:SGD;Acc:S000003436] [Ensembl]

Observation:

Deletion of ADE3 increases chronological lifespan [20421943].



Assays:

Classification:

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • MTHFD1 (9606)
  • MTHFD1 (9598)
  • MTHFD1 (9615)
  • MTHFD1 (9913)
  • Mthfd1 (10090)
  • Mthfd1 (10116)
  • MTHFD1 (9031)
  • mthfd1 (7955)
  • pug (7227)
  • AgaP_AGAP002830 (7165)
  • K07E3.4 (6239)
  • SPBC839.16 (4896)
  • ADE3 (4932)
  • KLLA0E16545g (28985)
  • AGOS_ACL121C (33169)
  • GeneID:2674667 (148305)
  • NCU03877 (5141)
  • THFS (3702)
  • Os09g0446800 (4530)



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