RPL6A

Symbol: RPL6A
Name: Ribosomal Protein of the Large subunit 6A
Alias: YL16A;L17A;L6A;YL16;rp18
Entrez gene ID: 854902
Ensembl gene ID: YML073C
Species: Yeast (Taxid: 4932)

Functional description:
Rpl6ap; N-terminally acetylated protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Bp and to rat L6 ribosomal protein; binds to 5.8S rRNA [Source:SGD;Acc:S000004538] [Ensembl]

Observation:

Deletion of RPL6A decrease mean replicative lifespan by 25% in the alpha strain [18340043; 18423200], but increases mean replicative lifespan by 40% in the remade strain. Its deletion non-significantly increases mean replicative lifespan in the ORF collection [22377630].



Interventions:
  • RPL6A deletion -25 to +40%

  • Assays: Replicative Lifespan
    Mean: +40

    Classification:
  • Aging-Suppressor
  • Positive Aging-Suppressor
  • Gerontogene
  • Negative Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • RPL6 (9606)
  • RPL6 (9598)
  • RPL6 (9615)
  • RPL6 (9615)
  • RPL6 (9913)
  • LOC782668 (9913)
  • LOC781724 (9913)
  • Rpl6 (10090)
  • Gm6136 (10090)
  • Gm6807 (10090)
  • Gm5428 (10090)
  • RPL6 (9031)
  • rpl6 (7955)
  • RpL6 (7227)
  • AgaP_AGAP001911 (7165)
  • rpl-6 (6239)
  • rpl6 (4896)
  • RPL6B (4932)
  • RPL6A (4932)
  • KLLA0B04686g (28985)
  • AGOS_AER149W (33169)
  • GeneID:2677964 (148305)
  • NCU02707 (5141)
  • AT1G74050 (3702)
  • AT1G18540 (3702)
  • AT1G74060 (3702)
  • Os04g0473400 (4530)
  • Os02g0591700 (4530)

  • Note: It is PG and NA. Its deletion non-significantly increases mean replicative lifespan in the ORF collection.

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