Denigma

cst-1

Symbol: cst-1
Name: Caenorhabditis STE20-like kinase 1
Entrez gene ID: 180708
Ensembl gene ID: F14H12.4
Species: Worm (Taxid: 6239)

Functional description:
Serine/threonine-protein kinase which extends lifespan and delays tissue aging, probably by activating daf-16. [UniProt]

Observation:

Knockdown of cst-1 shortens lifespan and accelerates tissue aging while its overexpression extends lifespan and delays aging in a daf-16-dependent manner [16751106].



Interventions:
  • cst-1 RNAi
  • cst-1 overexpression

    • Assays: Organismal Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor
  • Positive Aging-Suppressor


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • STK3 (9606)
  • STK3 (9598)
  • STK3 (9615)
  • STK3 (9913)
  • Stk3 (10090)
  • Stk3 (10116)
  • stk3 (7955)
  • hpo (7227)
  • AgaP_AGAP006044 (7165)
  • cst-1 (6239)
  • cst-2 (6239)



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