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Symbol: Men Name: Malic enzyme Entrez gene ID: 47173 Ensembl gene ID: FBgn0002719 Species: Fly (Taxid: 7227) Functional description: Malic enzyme; Malic enzyme [Source:FlyBase gene name;Acc:FBgn0002719] [Ensembl]; The gene Malic enzyme is referred to in FlyBase by the symbol Dmel\Men (CG10120, FBgn0002719). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity. There is experimental evidence that it is involved in the biological process: regulation of cell death. 84 alleles are reported. The phenotype of these alleles is annotated with: eye. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Malic enzyme, N-terminal; Malic enzyme, NAD-binding; Malic enzyme, conserved site; Malic oxidoreductase; NAD(P)-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, during late pupal stages, in adult male stages. [FlyBase] Observation: Overexpression of Men in males increases mean and maximum lifespan by 34% and 6%, respectively [22366109] Assays: Mean: 34 Maximum: 6 Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Inparanoids Edit \ Update (Admin) | Delete |
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