kis

Symbol: kis
Name: kismet
Alias: 136/31;2532;5841;anon-WO0172774.164;anon-WO0257455.5;BEST:GM02209;CG18326;CG3660;CG3696;Dmel\CG3696;EK2-4;GM02209;Kis;KIS;KIS-L;kiss;l(2)07812;l(2)k08827;l(2)k11324;l(2)k13631;l(2)k14112;l(2)k16510;l(2)s3527;l(2)s4771;l(2)s4793;Su(Pc)21AB
Entrez gene ID: 33185
Ensembl gene ID: FBgn0086902
Species: Fly (Taxid: 7227)

Functional description:
Kismet encodes a DNA helicase containing an SNF2-like ATPase domain, and functions in trithorax mediated chromating remodeling; kismet; kismet [Source:FlyBase gene name;Acc:FBgn0086902] [Ensembl]; The gene kismet is referred to in FlyBase by the symbol Dmel\kis (CG3696, FBgn0086902). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ATP-dependent helicase activity. There is experimental evidence for 12 unique biological process terms, many of which group under: cellular component organization or biogenesis; biological regulation; neuron differentiation; regionalization; system development; multicellular organismal development; immune response; localization; embryonic pattern specification; post-embryonic organ morphogenesis; segment specification; cellular process; short-term memory. 146 alleles are reported. The phenotypes of these alleles are annotated with: leg; eye; trichogen cell; mesothoracic tergum; wing; imaginal disc; wing vein. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: BRK domain; Chromo domain; Chromo domain-like; Chromo domain/shadow; DEAD-like helicase; Helicase, C-terminal; SNF2-related. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [FlyBase]

Observation:

Overexpression of kis increased mean and maximum lifespan by 24 - 36% and 23 - 28%, respectively [22366109].



Assays:
Mean: 24-36
Maximum: 23-28

Classification:

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • CHD7 (9606)
  • CHD7 (9598)
  • CHD7 (9615)
  • CHD7 (9913)
  • Chd7 (10090)
  • Chd7 (10116)
  • CHD7 (9031)
  • chd7 (7955)
  • kis (7227)
  • AgaP_AGAP008482 (7165)
  • tag-192 (6239)

  • Inparanoids
  • FBpp0289115 (7227)
  • ENSMUSP00000043903 (10090)
  • ENSRNOP00000018201 (10116)
  • ENSMMUP00000021427 (9544)
  • ENSP00000307304 (9606)



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