MUP1

Symbol: MUP1
Name: Methionine UPtake 1
Entrez gene ID: 852946
Ensembl gene ID: YGR055W
Species: Yeast (Taxid: 4932)

Functional description:
Mup1p; High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake [Source:SGD;Acc:S000003287] [Ensembl]

Observation:

Deletion of MUB1 extends mean and maximum replicative lifespan by 29 - 48% (29,48,43) and 20 - 23% (20,20,23), respectively. Mub1 is necessary for Ubr2-mediated Rpn4 ubiquitination. Lifespan extension conferred by MUP1 deletion is abrogated by RPN4 deletion, but not YAP1 deletion [21931558].



Assays:
Mean: +29-48
Maximum: +20-23

Classification:

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • aat-9 (6239)
  • aat-5 (6239)
  • aat-4 (6239)
  • aat-7 (6239)
  • aat-6 (6239)
  • aat-8 (6239)
  • MUP1 (4932)
  • KLLA0B13233g (28985)
  • AGOS_ABL003C (33169)
  • NCU07754 (5141)



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