Symbol: RPN4 Name: Regulatory Particle Non-ATPase 4 Alias: SON1;UFD5 Entrez gene ID: 851542 Ensembl gene ID: YDL020C Species: Yeast (Taxid: 4932) Functional description: Rpn4p; Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses [Source:SGD;Acc:S000002178] [Ensembl] Observation: Deletion mutants of the C2H2 zinc-finger transcription factor RPN4, are characterized by a reduced non-adaptable proteasome pool and display a 37 - 53% and 22-33% reduction in mean and maximum replicative lifespan. TOR1 deletion extends rpn4 replicative lifespan. Severe DR by reducing glucose concentration to 0.05% increased replicative lifespan of rpn4 mutants. RPN4 transcription is controlled by HSF1 [21931558]. Assays: Mean: -37-53 Maximum: -22-33 Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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