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Symbol: RPL6 Name: Regulatory Particle Triple-A protein, or Regulatory Particle Triphosphatase 6 Alias: CIM3;CRL3;SCB6 Entrez gene ID: 852834 Ensembl gene ID: YGL048C Species: Yeast (Taxid: 4932) Functional description: Rpt6p; One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle [Source:SGD;Acc:S000003016] [Ensembl] Observation: Mutation of RPL6 decreases mean (-63%) and maximum (-51%) replicative lifespan [21931558]. Assays: Mean: -51 Maximum: -63 Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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