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Symbol: crn-5 Name: Cell-death-Related Nuclease 5 Entrez gene ID: 174634 Ensembl gene ID: C14A4.5 Species: Worm (Taxid: 6239) Functional description: Protein CRN-5; Cell-death-Related Nuclease family member (crn-5) [Source:RefSeq peptide;Acc:NP_496284] [Ensembl]; crn-5 encodes a cell death-related nuclease which is a homolog of Rrp46, an eukaryotic ribonulease component of the exosome, involved in RNA processing; crn-5 is believed to function in a large multinuclease complex, the degradeosome, whose components include the protein products of cps-6, crn-1, crn-4, cpy-13 and other non-nuclease components like wah-1, to promote apoptotic DNA degradation; crn-5 has been shown to bind DNA without detectable DNase activity but enhances the DNase activity of CRN-4, a DEDD family apoptotic DNAase and RNase. [WormBase] Observation: RNA interference against crn-5 in adulthood results in a 41% increase in mean lifespan [17411345]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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