RPT1

Symbol: RPT1
Name: Regulatory Particle Triple-A protein, or Regulatory Particle Triphosphatase
Alias: CIM5;YTA3
Entrez gene ID: 853712
Ensembl gene ID: YKL145W
Species: Yeast (Taxid: 4932)

Functional description:
Rpt1p; One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance [Source:SGD;Acc:S000001628] [Ensembl]

Observation:

Mutation of RPT1 decreases mean (-33%) and maximum (-14%) replicative lifespan [21931558].



Assays:
Mean: -33
Maximum: -14

Classification:

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • PSMC2 (9606)
  • PSMC2 (9598)
  • PSMC2 (9615)
  • Psmc2 (10090)
  • Psmc2 (10116)
  • PSMC2 (9031)
  • psmc2 (7955)
  • Rpt1 (7227)
  • AgaP_AGAP011174 (7165)
  • rpt-1 (6239)
  • rpt1 (4896)
  • RPT1 (4932)
  • KLLA0E13773g (28985)
  • AGOS_ACR050C (33169)
  • GeneID:2679295 (148305)
  • NCU02840 (5141)
  • RPT1A (3702)
  • Os06g0192600 (4530)
  • PF13_0063 (5833)



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