Symbol: RPT1 Name: Regulatory Particle Triple-A protein, or Regulatory Particle Triphosphatase Alias: CIM5;YTA3 Entrez gene ID: 853712 Ensembl gene ID: YKL145W Species: Yeast (Taxid: 4932) Functional description: Rpt1p; One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance [Source:SGD;Acc:S000001628] [Ensembl] Observation: Mutation of RPT1 decreases mean (-33%) and maximum (-14%) replicative lifespan [21931558]. Assays: Mean: -33 Maximum: -14 Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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