vang-1

Symbol: vang-1
Name: VANG (Van Gogh/Strabismus planar polarity protein) homolog)
Entrez gene ID: 180579
Ensembl gene ID: B0410.2
Species: Worm (Taxid: 6239)

Functional description:
Protein VANG-1; VANG (Van Gogh/Strabismus planar polarity protein) homolog family member (vang-1) [Source:RefSeq peptide;Acc:NP_508500] [Ensembl]; vang-1 encodes an ortholog of Drosophila VAN GOGH (also known as STRABISMUS); VANG-1 enables Wnt-directed planar cell polarity; VANG-1 is required for the fully asymmetrical division of B.a versus B.p cells, though this requirement is quantitatively weak. [WormBase]

Observation:

Loss-of-function of VANG-1 (the only C. elegans orthoholog of the conserved PCP component Strabismus/Van Gogh) via mutant alleles (at 25, 20 and 18 degree Celsius) or RNAi cause an increase of mean lifespan up to 40% and 27 to 20%, respectively. Longevity phenotype of vang-1 loss-of-function animals is associated with enhanced resistance to thermal and oxidative stress, decreased lipofuscin accumulation and lowerd ROS accumulation as well as reduced brood size, decreased ovulation rate and prolonged reproductive span. The germline rather than somatic tissues, such as intestine or neurons ,appear to be the primary site of vang-1 function. Lifespan extension via vang-1 mutation depends on DAF-2 and DAF-16 as well as SKN-1.



Assays:
Mean: 40

Classification:

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • VANGL1 (9606)
  • VANGL1 (9598)
  • VANGL1 (9615)
  • VANGL1 (9913)
  • Vangl1 (10090)
  • Vangl1 (10116)
  • VANGL1 (9031)
  • vangl1 (7955)
  • Vang (7227)
  • AgaP_AGAP012288 (7165)
  • vang-1 (6239)



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