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Symbol: elo-1 Name: fatty acid ELOngation 1 Entrez gene ID: 177787 Ensembl gene ID: F56H11.4 Species: Worm (Taxid: 6239) Functional description: Protein ELO-1; fatty acid ELOngation family member (elo-1) [Source:RefSeq peptide;Acc:NP_501689] [Ensembl]; elo-1 encodes a component of C-18 polyunsaturated fatty acid (PUFA) elongase that is required for normal elongation of n-6 and n-3 20-carbon PUFA in vivo; ELO-1 is a condensing enzyme that elongates n-6 and n-7 (and, with less efficiency, n-3) series C18 PUFAs. [WormBase] Observation: elo-1 RNAi at adulthood extends lifespan by 11%, while in combination with elo-2 (substantial functional redundant) increases lifespan by 15% [21386131]. Interventions: Assays: Organismal Lifespan Median: 11 Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Orthologs Edit \ Update (Admin) | Delete |
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