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Symbol: Cbs Alias: dCBS; CG1753 Entrez gene ID: 33081 Ensembl gene ID: FBgn0031148 Species: Fly (Taxid: 7227) Functional description: Catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway.; CG1753 gene product from transcript CG1753-RA; The gene Cystathionine β-synthase is referred to in FlyBase by the symbol Dmel\Cbs (CG1753, FBgn0031148). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: cystathionine beta-synthase activity. There is experimental evidence that it is involved in the biological process: determination of adult lifespan. 8 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Cystathionine beta-synthase; Cystathionine beta-synthase, core; Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site; Pyridoxal phosphate-dependent enzyme, beta subunit. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed during early larval stages. [FlyBase] Observation: Ubiquitous or neuron-specific transgenic overexpression of Cbs enhances longevity in fully-fed animals. Cbs RNAi partially abrogates increased lifespan by DR, but has no effect on fully fed animals. Cbs upregulation is required for increased lifespan under low-nutrient conditions. Response of male flies to DR is muted in comparison with females. Adult-specific ubiquitous expression of Cbs is sufficient to increase female mean and maximum lifespan by 12 - 43% and 10%, respectively. Males, whose lifespan is relatively less affected by DR, exhibite a smaller, but still significant increase in lifespan by 7% upon Cbs overexpression. Neuronal overexpression also increases lifespan, albeit modestly (approximately 12% mean and 15% maximum lifespan extension), whereas overexpression in the fat body and in the gut has no effect [21930912]. Interventions: Assays: Organismal Lifespan Mean: +7 to +43 Maximum: +10 to +15 Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Inparanoids Edit \ Update (Admin) | Delete |
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