Symbol: MRPL25 Name: Mitochondrial Ribosomal Protein, Large subunit 25 Alias: AFO1;YMR26;YmL25 Entrez gene ID: 852967 Ensembl gene ID: YGR076C Species: Yeast (Taxid: 4932) Functional description: Mrpl25p; Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000003308] [Ensembl] Observation: MRPL25/AFO1 (aging factor one) deletion confers increase in mean and maximum replicative lifespan by 60% and 40%, respectively. AFO1 encodes a protein that is contained in the large subunit of the mitochondrial ribososme. Lifespan extension by afo1 is independent of mitochondrial translation and formation of extrachromosomal ribosomal-DNA circles, but involves cytoplasmic Tor1 as well as Sfp1 [20157544]. Assays: Mean: +60 Maximum: +40 Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
Comment on This Data Unit