Denigma

ACB1

Symbol: ACB1
Name: Acyl-CoA-Binding 1
Entrez gene ID: 852925
Ensembl gene ID: YGR037C
Species: Yeast (Taxid: 4932)

Functional description:
Acb1p; Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion [Source:SGD;Acc:S000003269] [Ensembl]

Observation:

ACB1 deletion extends chronological lifespan under starvation/extreme DR. Similar heat-shock resistance and resistance to a very hight concentration of acetic acid (but not resistance to oxidative stress) was enhanced by the deletion of ACB1. Deletion of ACB1 in W303-1A and DBY746 genetic backgrounds on synthetic complete media causes severe growth defects and sightly shorter lifespan and also heat-sensitivity [20657825].



Interventions:
  • ACB1 deletion

    • Assays: Chronological Lifespan

    Classification:
  • Aging Associated


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • DBI (9606)
  • DBI (9598)
  • DBI (9615)
  • DBI (9913)
  • Dbi (10090)
  • Dbi (10116)
  • DBI (9031)
  • zgc:77734 (7955)
  • Dbi (7227)
  • AgaP_AGAP007460 (7165)
  • acbp-1 (6239)
  • SPBC1539.06 (4896)
  • ACB1 (4932)
  • AGOS_ACL188W (33169)

    • Note: Strain and diet specific effects?

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