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Symbol: LEU3 Name: LEUcine biosynthesis 3 Entrez gene ID: 851172 Ensembl gene ID: YLR451W Species: Yeast (Taxid: 4932) Functional description: Leu3p; Zinc-finger transcription factor that regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; positively regulated by alpha-isopropylmalate, an intermediate in leucine biosynthesis [Source:SGD;Acc:S000004443] [Ensembl]; Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation [SGD] Observation: LEU3 deletion dramatically increases chronological lifespan [19302372]. Interventions: Assays: Replicative Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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