YPT6

Symbol: YPT6
Name: Yeast Protein Two 6
Entrez gene ID: 850966
Ensembl gene ID: YLR262C
Species: Yeast (Taxid: 4932)

Functional description:
Ypt6p; Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6 [Source:SGD;Acc:S000004252] [Ensembl]

Observation:

Deletion of YPT6 increases replicative lifespan by 20% [19030232]. YPT6 deletion increases replicative lifespan by 30% in the alpha strain and by 10% in the a strain [18340043].



Interventions:
  • YPT6 deletion +10 to +30%

  • Assays: Replicative Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • RAB6B (9606)
  • RAB6B (9598)
  • RAB6B (9615)
  • RAB6B (9913)
  • Rab6b (10090)
  • Rab6b (10116)
  • rab6b (7955)
  • rab-6.1 (6239)
  • ryh1 (4896)
  • YPT6 (4932)
  • KLLA0F20471g (28985)
  • AGOS_AGR257C (33169)
  • GeneID:2677653 (148305)
  • NCU05234 (5141)
  • RAB6A (3702)
  • Os07g0496000 (4530)



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