Symbol: clk-1 Name: CLocK (biological timing) abnormality 1 Alias: coq-1; coq-7 Entrez gene ID: 175729 Ensembl gene ID: ZC395.2 Species: Worm (Taxid: 6239) Functional description: Plays a role in biological timing and in longevity. [UniProt] Observation: Mutations in clk-1 slow down development and extend lifespan by 30%. Mutation of both clk-1 and daf-2 results in nearly 5-fold (500%) increase in lifespan [8638122]. Food restriction by eat-2 mutation does not further extend the long lifespan of clk-1 mutant [9789046]. DR and clk-1 mutations may extend lifespan by a similar process. DR by intermittent fasting (IF) significantly extends lifespan of clk-1 mutants, but to a lesser extent than that of wild-type [19079239]. clk-1 mutants do not respond to sDR-induced lifespan extension [19239417]. Overexpression of clk-1 shortens lifespan and is associated with increased mitochondrial activity [10202142]. Transgenic overexpression of mouse Coq7 reverts the extended lifespan of clk-1 mutants [11511092]. clk-1 encodes a enzyme participating in coenzyme Q synthesis [9020081; 11136229]. clk-1 mutants have a decreased pharyngeal pumping and may provoke volunteering DR [9789046]. Mutations in clk-1 are highly pleiotropic resulting in an average lengthing of embryonic development, post-embryonic development, and adult rhythmic behaviours such as defecation, swimming and pharyngeal pumping [7768437]. clk-1 mutants require coeznyme Q [11136229]. clk-1 protein binds the mitochondrial O(L) region and may regulate replication of mitochondrial DNA [11959146]. Interventions: Assays: Organismal Lifespan Classification: References: Aging Relevance Analysis/Source: Homologs Orthologs Note: Heterozygous knockouts live, on average, 31% longer [11511092]. Edit \ Update (Admin) | Delete |
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