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Symbol: VMS1 Name: VCP/Cdc48-associated Mitochondrial Stress-responsive 1 Entrez gene ID: 851618 Ensembl gene ID: YDR049W Species: Yeast (Taxid: 4932) Functional description: may be involved in altering acetylation on histone lysines; Vms1p; Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their u /.../ination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans [Source:SGD;Acc:S000002456] [Ensembl]; Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans [SGD] Observation: Deletion of VMS1 decreases replicative lifespan by 25% in the alpha strain [19030232]. Interventions: Assays: Replicative Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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