Denigma

YDC1

Symbol: YDC1
Name: Yeast DihydroCeramidase 1
Entrez gene ID: 856018
Ensembl gene ID: YPL087W
Species: Yeast (Taxid: 4932)

Functional description:
Ydc1p; Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity [Source:SGD;Acc:S000006008] [Ensembl]

Observation:

Overexpression of YDC1 decreases chronological lifespan by 40% [19059240]



Interventions:
  • YDC1 overexpression -40%

    • Assays: Chronological Lifespan

    Classification:
  • Gerontogene
  • Negative Gerontogene


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • ACER3 (9606)
  • ACER3 (9598)
  • ACER3 (9615)
  • ACER3 (9913)
  • Acer3 (10090)
  • Acer3 (10116)
  • PHCA (9031)
  • LOC555411 (7955)
  • YDC1 (4932)
  • YPC1 (4932)
  • KLLA0E23981g (28985)
  • GeneID:2675865 (148305)
  • NCU02969 (5141)
  • ATCES1 (3702)
  • Os03g0698900 (4530)

    • Note: Does deletion of YDC1 increase chronological lifespan [Aerts et al., 2008].

    Edit \ Update (Admin) | Delete

    Comment on This Data Unit