cit-1.2

Symbol: cit-1.2
Name: CyclIn T 1.2
Entrez gene ID: 176126
Ensembl gene ID: F44B9.3
Species: Worm (Taxid: 6239)

Functional description:
Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II). [UniProt]

Observation:

RNA interference cit-1.2 decreases median lifespan by 27% in daf-2 mutants [18006689].



Interventions:
  • cit-1.2 RNAi -27%

  • Assays: Organismal Lifespan

    Classification:
  • Aging Associated


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • CCNT1 (9606)
  • CCNT1 (9598)
  • CCNT1 (9615)
  • CCNT1 (9913)
  • Ccnt1 (10090)
  • Ccnt1 (10116)
  • si:dkey-18f23.10 (7955)
  • CycT (7227)
  • AgaP_AGAP006678 (7165)
  • cit-1.2 (6239)
  • AT5G45190 (3702)
  • CYCT1;4 (3702)
  • Os12g0485400 (4530)



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