Denigma: Factor

TMA19

Symbol: TMA19
Name: Translation Machinery Associated 19
Entrez gene ID: 853809
Ensembl gene ID: YKL056C
Species: Yeast (Taxid: 4932)

Functional description:
Tma19p; Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress [Source:SGD;Acc:S000001539] [Ensembl]

Observation:

Deletion of TMA19 increases replicative lifespan by 16% (P<0.02) [16806052]. TMA19 deletion increases replicative lifespan by 25-30% in the alpha and a strains [19030232].

Interventions:

TMA19 deletion +25 to +30% +16%

Assays: Replicative Lifespan

Classification:

Gerontogene

Positive Gerontogene

Aging Relevance Analysis/Source:

GenAge