Denigma: Factor

TIF4631

Symbol: TIF4631
Name: Translation Initiation Factor 4631
Entrez gene ID: 853071
Ensembl gene ID: YGR162W
Species: Yeast (Taxid: 4932)

Functional description:
Tif4631p; Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit [Source:SGD;Acc:S000003394] [Ensembl]

Observation:

Deletion of TIF4631 increases replicative lifespan by 20% in the alpha and a strains [18340043]. TIF4631 increases replicative lifespan by 10-20% in the alpha and a strains [19030232].

Interventions:

TIF4631 deletion +10 to 20%

Assays: Replicative Lifespan

Classification:

Gerontogene

Positive Gerontogene

Aging Relevance Analysis/Source:

GenAge