Denigma: Factor

TIF1

Symbol: TIF1
Name: Translation Initiation Factor 1
Entrez gene ID: 853933
Ensembl gene ID: YKR059W
Species: Yeast (Taxid: 4932)

Functional description:
Tif1p; Translation initiation factor eIF4A, identical to Tif2p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G [Source:SGD;Acc:S000001767] [Ensembl]

Observation:

Deletion of TIF1 increases replicative lifespan by 20% in the alpha strain [19030232]. TIF1 deletion increases by 30% in the alpha strain and 15% in the a strain [18340043].

Interventions:

TIF1 deletion +15 to +30%

Assays: Replicative Lifespan

Classification:

Gerontogene

Positive Gerontogene

Aging Relevance Analysis/Source:

GenAge