Denigma: Factor

SRS2

Symbol: SRS2
Name: DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; affects genome stability by suppressing unscheduled homologous recombination
Alias: HPR5
Entrez gene ID: 853353
Ensembl gene ID: YJL092W
Species: Yeast (Taxid: 4932)

Functional description:
Srs2p; DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability [Source:SGD;Acc:S000003628] [Ensembl]

Observation:

SRS2 deletion mutants have a shortened mean replicative lifespan (by 50%) similar to sgs1 mutants [11290710]. Overexpression of SGS1 increases maximum, but not mean lifespan of SRS2 mutants [11861900]. Deletion of SRS2 is synthetical lethal in combination with deletion of SGS1 [11290710].

Interventions:

SRS2 deletion -50%

Assays: Replicative Lifespan

Classification:

Aging-Suppressor

Negative Aging-Suppressor

References:

11290710: The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination.

Aging Relevance Analysis/Source:

GenAge