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Symbol: che-2 Name: abnormal CHEmotaxis Entrez gene ID: 180401 Ensembl gene ID: F38G1.1 Species: Worm (Taxid: 6239) Functional description: Protein CHE-2; abnormal CHEmotaxis family member (che-2) [Source:RefSeq peptide;Acc:NP_508106] [Ensembl]; che-2 encodes a protein that contains G-protein beta-like WD-40 repeats that affects chemotaxis, dauer formation, and longevity; expressed in the cilia of most ciliated sensory neurons, some head neurons, and male tail rays. [WormBase] Observation: che-2 recessive loss-of-function mutations extend lifespan up to 50% (in Bristol N2) [10617200]. che-2 mutants are chemotactic defective, slightly small, defective for osmotic avoidance, have ciliated neurons with abnormal stunted ultrastructure, and are dauer defective [2428682; 1732156]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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