che-13

Symbol: che-13
Name: abnormal CHEmotaxis
Entrez gene ID: 186607
Ensembl gene ID: F59C6.7
Species: Worm (Taxid: 6239)

Functional description:
Required for the formation of chemosensory cilia that detect chemosensory cues. Involved in intraflagellar transport along the cilia axoneme. [UniProt]

Observation:

Loss-of-function mutation in che-13 increases lifespan up to 40% (in Bristol N2) [10617200]. che-13 Mutants are dye filling defective, have severely shortened axonemes and ectopic assembly of ciliary structures and microtubules in many sensory neurons as well as are defective in osmotic avoidance and dauer defective [2428682].



Interventions:
  • che-13 mutation +40%

  • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • IFT57 (9606)
  • IFT57 (9598)
  • IFT57 (9615)
  • IFT57 (9913)
  • Ift57 (10090)
  • Ift57 (10116)
  • IFT57 (9031)
  • ift57 (7955)
  • CG8853 (7227)
  • AgaP_AGAP008872 (7165)
  • che-13 (6239)



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