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Symbol: che-11 Name: abnormal CHEmotaxis Entrez gene ID: 179666 Ensembl gene ID: C27A7.4 Species: Worm (Taxid: 6239) Functional description: Protein CHE-11; abnormal CHEmotaxis family member (che-11) [Source:RefSeq peptide;Acc:NP_506047] [Ensembl]; che-11 encodes a large, unfamiliar protein with orthologs in vertebrates and arthropods (e.g., KIAA0590 and CG11838-PA) and in Chlamydomonas (IFT140), as well as distant similarity to OSM-1 and ZK520.1; che-11 is required for normal synthesis of sensory cilia (via intraflagellar transport) in sensory neurons, osmotic avoidance, and dauer formation. [WormBase] Observation: Loss-of-function muation in che-11 increases lifespan up to 40% (in Bristol N2) [10617200]. che-11 mutants are dye filling defective, defective in osmotic avoidance and dauer formation, and have irregular amphid cilia [2428682]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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