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Symbol: cert Name: ceramide transfer protein Alias: CG7207 Entrez gene ID: 38928 Ensembl gene ID: FBgn0027569 Species: Fly (Taxid: 7227) Functional description: ceramide transfer protein; ceramide transfer protein [Source:FlyBase gene name;Acc:FBgn0027569] [Ensembl]; The gene ceramide transfer protein is referred to in FlyBase by the symbol Dmel\cert (CG7207, FBgn0027569). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: ceramide binding; ceramide transporter activity. There is experimental evidence that it is involved in the biological process: sphingolipid metabolic process; ceramide transport. 9 alleles are reported. The phenotype of these alleles is annotated with: plasma membrane. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Lipid-binding START; Pleckstrin homology domain; Pleckstrin homology-type; START-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during early pupal stages. [FlyBase] Observation: cert mutants exhibit a shortened lifespan accompanied by enhanced oxidative damage to cellular proteins and metabolic compromise, such as increasing glucose levels, reminiscent of premature aging [17592126]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Inparanoids Edit \ Update (Admin) | Delete |
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