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Symbol: RPL12B Name: Ribosomal Protein of the Large subunit 12B Alias: L12B;L15B;YL23 Entrez gene ID: 852026 Ensembl gene ID: YDR418W Species: Yeast (Taxid: 4932) Functional description: Rpl12bp; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins [Source:SGD;Acc:S000002826] [Ensembl] Observation: Deletion of RPL12B increases mean replicative lifespan by 20% in the alpha strain [18423200] and by 22% in the remade strain, but increases non-significantly the mean replicative lifespan by 13% in the ORF collection [22377630]. RPL12B mutation promotes mean chronological longevity extension and heat-shock resistance but reduces acetic acid resistance under starvation/extreme DR. In DBY746 mutation of RPL12B almost doubles mean chronological lifespan in SDC medium and increases heat-shock resistance [20657825] Interventions: Assays: Replicative Lifespan Chronological Lifespan Mean: +20-22 Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Note: Did non-significantly increases mean replicative lifespan by 13% in the ORF collection. Edit \ Update (Admin) | Delete |
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