Symbol: RIF1 Name: RAP1-Interacting Factor 1 Entrez gene ID: 852578 Ensembl gene ID: YBR275C Species: Yeast (Taxid: 4932) Functional description: Rif1p; Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation [Source:SGD;Acc:S000000479] [Ensembl] Observation: Deletion of RIF1 decrease replicative lifespan by 40% [9275199]. RIF1 deletion increases telomere silencing and length [8319907; 1577274], and therefore likely recruits SIR2 from rDNA to the telomeres which result in lifespan shortening. The sir4-42 allele suppresses the short lifespan of a RIF1 mutant [9275199]. Interventions: Assays: Replicative Lifespan Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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