RIF1

Symbol: RIF1
Name: RAP1-Interacting Factor 1
Entrez gene ID: 852578
Ensembl gene ID: YBR275C
Species: Yeast (Taxid: 4932)

Functional description:
Rif1p; Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation [Source:SGD;Acc:S000000479] [Ensembl]

Observation:

Deletion of RIF1 decrease replicative lifespan by 40% [9275199]. RIF1 deletion increases telomere silencing and length [8319907; 1577274], and therefore likely recruits SIR2 from rDNA to the telomeres which result in lifespan shortening. The sir4-42 allele suppresses the short lifespan of a RIF1 mutant [9275199].



Interventions:
  • RIF deletion -40%

  • Assays: Replicative Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • RIF1 (4932)
  • KLLA0F01254g (28985)
  • AGOS_AEL186W (33169)



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