Denigma

CDC25

Symbol: CDC25
Name: Cell Division Cycle 25
Alias: CTN1
Entrez gene ID: 851019
Ensembl gene ID: YLR310C
Species: Yeast (Taxid: 4932)

Functional description:
Cdc25p; Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1 [Source:SGD;Acc:S000004301] [Ensembl]

Observation:

The CDC25-10 allele extends mean and maximum replicative lifespan by 34% and 18%, respectively, at 30 degree Celsius. cdc25-10 mutants have an extended replicative lifespan under AL. Growth on 0.5% glucose restriction does not further extend replicative lifespan of cdc25-10 mutants. CDC25 null mutant is not viable. CDC25 appears to act in the same genetic pathway as SIR2 and NPT1 and is suggested to be genetic model of DR [11000115].



Interventions:
  • CDC25 mutation +34% +18%

    • Assays: Replicative Lifespan
    Mean: +34
    Maximum: +18

    Classification:
  • Gerontogene
  • Positive Gerontogene
  • DR-Essential


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • CDC25 (4932)
  • KLLA0D09306g (28985)
  • AGOS_ADL038W (33169)

    • Orthologs
  • C3G (7227)
  • Sos2 (10116)
  • Rapgef1 (10116)
  • RAPGEF1 (9544)
  • CG5522 (7227)
  • LOC100361774 (10116)
  • Ralgps1 (10090)
  • sos-1 (6239)
  • RALGPS2 (9544)
  • RALGPS1 (9606)
  • Ralgps2 (10090)
  • SOS1 (9544)
  • Sos1 (10090)
  • Sos2 (10090)
  • Y34B4A.4 (6239)
  • Sos1 (10116)
  • RAPGEF1 (9606)
  • Rapgef1 (10090)
  • Sos (7227)
  • SOS2 (9544)
  • RALGPS2 (9544)
  • Ralgps2 (10116)
  • RALGPS2 (9606)
  • SOS1 (9606)
  • SOS2 (9606)
  • C3G (7227)
  • Sos2 (10116)
  • Rapgef1 (10116)
  • RAPGEF1 (9544)
  • CG5522 (7227)
  • LOC100361774 (10116)
  • Ralgps1 (10090)
  • sos-1 (6239)
  • RALGPS2 (9544)
  • RALGPS1 (9606)
  • Ralgps2 (10090)
  • SOS1 (9544)
  • Sos1 (10090)
  • Sos2 (10090)
  • Y34B4A.4 (6239)
  • Sos1 (10116)
  • RAPGEF1 (9606)
  • Rapgef1 (10090)
  • Sos (7227)
  • SOS2 (9544)
  • RALGPS2 (9544)
  • Ralgps2 (10116)
  • RALGPS2 (9606)
  • SOS1 (9606)
  • SOS2 (9606)
  • C3G (7227)
  • Sos2 (10116)
  • Rapgef1 (10116)
  • RAPGEF1 (9544)
  • CG5522 (7227)
  • LOC100361774 (10116)
  • Ralgps1 (10090)
  • sos-1 (6239)
  • RALGPS2 (9544)
  • RALGPS1 (9606)
  • Ralgps2 (10090)
  • SOS1 (9544)
  • Sos1 (10090)
  • Sos2 (10090)
  • Y34B4A.4 (6239)
  • Sos1 (10116)
  • RAPGEF1 (9606)
  • Rapgef1 (10090)
  • Sos (7227)
  • SOS2 (9544)
  • RALGPS2 (9544)
  • Ralgps2 (10116)
  • RALGPS2 (9606)
  • SOS1 (9606)
  • SOS2 (9606)



    • Edit \ Update (Admin) | Delete

    Comment on This Data Unit