Symbol: PKH2 Name: Pkb-activating Kinase Homolog 2 Entrez gene ID: 854053 Ensembl gene ID: YOL100W Species: Yeast (Taxid: 4932) Functional description: Pkh2p; Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p [Source:SGD;Acc:S000005460] [Ensembl] Observation: PKH2 deletion increases replicative lifespan by 20% in the alpha strain and by 15% in the a strain [18340043]. Deletion of PKH2 increases chronological lifespan by 29% [22319457] to 34% [21447998] as well as by 19 - 54% (19, 24, 29, 54) in diploid cells [21447998]. PKH2 mutation extends both replicative and chronological lifespan as well as cancels out DR-induced replicative and chronological lifespan extension [21584246]. Mean and maximum replicative lifespan on AL is extended by 38 and 69%, respectively. Interventions: Assays: Replicative Lifespan Chronological Lifespan Mean: +15 to +54 Maximum: +69 Classification: Aging Relevance Analysis/Source: Homologs Orthologs Edit \ Update (Admin) | Delete |
Comment on This Data Unit