PKH2

Symbol: PKH2
Name: Pkb-activating Kinase Homolog 2
Entrez gene ID: 854053
Ensembl gene ID: YOL100W
Species: Yeast (Taxid: 4932)

Functional description:
Pkh2p; Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p [Source:SGD;Acc:S000005460] [Ensembl]

Observation:

PKH2 deletion increases replicative lifespan by 20% in the alpha strain and by 15% in the a strain [18340043]. Deletion of PKH2 increases chronological lifespan by 29% [22319457] to 34% [21447998] as well as by 19 - 54% (19, 24, 29, 54) in diploid cells [21447998]. PKH2 mutation extends both replicative and chronological lifespan as well as cancels out DR-induced replicative and chronological lifespan extension [21584246]. Mean and maximum replicative lifespan on AL is extended by 38 and 69%, respectively.



Interventions:
  • PKH2 deletion +15 to +54% +69%

  • Assays: Replicative Lifespan Chronological Lifespan
    Mean: +15 to +54
    Maximum: +69

    Classification:
  • Gerontogene
  • Positive Gerontogene
  • DR-Essential


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • PKH2 (4932)
  • KLLA0C12485g (28985)
  • AGOS_AFR335C (33169)

  • Orthologs
  • W04B5.5 (6239)
  • Pk61C (7227)
  • LOC100509979 (9606)
  • Pdpk1 (10090)
  • Pdpk1 (10116)
  • PDPK1 (9606)
  • pdk-1 (6239)
  • LOC697523 (9544)
  • W04B5.5 (6239)
  • Pk61C (7227)
  • LOC100509979 (9606)
  • PKH1 (4932)
  • PKH3 (4932)
  • Pdpk1 (10090)
  • Pdpk1 (10116)
  • PDPK1 (9606)
  • pdk-1 (6239)
  • LOC697523 (9544)



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