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Symbol: PGA3 Name: Processing of Gas1p and ALP Alias: NQR1 Entrez gene ID: 854914 Ensembl gene ID: YML125C Species: Yeast (Taxid: 4932) Functional description: Pga3p; Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking [Source:SGD;Acc:S000004594] [Ensembl] Observation: Low glucose condition induces expression and activity of plasma membrane NADH coenzyme Q reductase (PGA3). Overexpression of PGA3 extends replicative and chronological lifespan by 20-30% [19239415]. Assays: Replicative Lifespan Chronological Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Orthologs Edit \ Update (Admin) | Delete |
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